Herbal Advantage, Inc. Candidate for a VAP Test.

Herbal Advantage, Inc. Who is a candidate for a VAP Test?

Uncontrollable Risk Factors	Controllable Risk Factors
Patients with CAD or a family history of CAD	Cigarette Smoking
Post-Menopausal women	Adults or children at least 30 pounds overweight
History of elevated TC, LDL, TG (Triglycerides) or low HDL	High Blood Pressure
Hypertension	High Cholesterol
Heart-by-pass or angioplasty	Physical Activity
Patient with stroke or family history of stroke	Diabetes
Aging and Male Gender	Stress

COMPONENTS OF THE VAP TEST include direct measured LDL, HDL, VLDL, TC with TG and LDL/HDL RATIO and TC/HDL RATIO. Additional important lipoprotein risk factors include:

Lp(a) The "heart attack" cholesterol. A direct risk factor for CAD and high levels are a predictor of stroke and post angioplasty rest enosis in many cases.

HDL₂ The "best" cholesterol. Low HDL₂ is a risk factor for CAD in patients with normal cholesterol.

HDL₃ The least protective HDL. TC/lipid panel don't distinguish between HDL₂ and HDL₃

IDL "Bad" non-LDL cholesterol. Independent risk factor for CAD.

VLDL₃ A predictor of the severity of CAD. The most dense (bad) element of triglyceride.

Pattern A, B or A/B "A" is the (good) atherogenic of the LDL subclasses, "B" is an independent risk factor for CAD—the most atherogenic (bad) of the HDL sub classes and "A/B" is intermediate in atherogenicity.

Accuracy of VAP is ensured by extensive quality control procedures. Variability of results is minimized by constant monitoring of total and lipoprotein cholesterol values in the control; rotors whose control values are out of acceptable range are repeated. Accuracy is ensured by frequent comparison of random samples with results from NWLRL, and participation in the AAB Proficiency program.

References

1. Chung, B. H., Wilkinson, T., Geer, J. C. and Segrest, J. P.: Preparative and quantitative isolation of plasma lipoproteins: Rapid, single discontinuous density gradient ultracentrifugation in a vertical rotor J. Lipid Re. 2:284-291, 1980.

2. Chung, B. H., Segrest, J. P., Pfau, J., Geer, J. C. and Cone, J. T.: High resolution plasma lipoprotein cholesterol profiles by a rapid, high volume automated method J. Lipid Res. 22:1003- 1014,1981.

3. Cone, J. T., Segrest, J. P., Chung, B. H., Ragland, J. B., Sabesin, S. M. and Glasscock, M. A.: Computerized rapid high resolution quantitative analysis of plasma lipoproteins based upon single vertical spin centrifugation. J. Lipid Res. 23:923-935, 1982.

4. Chung, B. H., Segrest, J. P., Ray, M. J., Brunzell, J. D., Hokanson, J. E., Krauss, R. M., Beaudrie, K. and Cone, J. T.: Single vertical spin density gradient ultracentrifugation. Methods in Enzymology, Vol. 128. (Academic Press, N.Y.), Vol. 128, pp. 181-209, 1986.

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131 Bobwhite Road, Rogersville, Missouri, 65742, USA
Telephone: 417-753-4000 or 800-753-9199, Fax: 417-753-2000
Last Updated: 08-17-02 by SJM